Assay Detail
Binding
CHEMBL5374057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs followed by biotinylated lipid pocket probe addition and measured after 60 min by TR-FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transcriptional enhancer factor TEF-4 (CHEMBL4523301) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Indazole Compounds as TEAD Inhibitors for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5411200 | — | — | 1 | 8.70 |
| CHEMBL5408536 | — | — | 1 | 8.52 |
| CHEMBL5403826 | — | — | 1 | 8.52 |
| CHEMBL5432828 | — | — | 1 | 8.40 |
| CHEMBL5438256 | — | — | 1 | 8.05 |
| CHEMBL5428867 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5411200 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5408536 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5403826 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5432828 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5438256 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5428867 | — | IC50 | = | 17.0 | nM | 7.77 |