Compound Detail
CHEMBL5432828
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Basic Information
| ChEMBL ID | CHEMBL5432828 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FATYKAPPXHGOKR-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
418.4
MW (Da)
2.92
ALogP
6
HBA
1
HBD
80.5
PSA (Ų)
0.64
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transcriptional enhancer factor TEF-3 CHEMBL4295828 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Transcriptional enhancer factor TEF-4 CHEMBL4523301 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Transcriptional enhancer factor TEF-5 CHEMBL4523435 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
| Transcriptional enhancer factor TEF-1 CHEMBL3334416 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transcriptional enhancer factor TEF-3 | IC50 | = | 3.0 | nM | 8.52 | Inhibition of His-tagged TEAD4 (unknown origin) preincubated for 0.5 to 4 hrs fo... | 37849539 |
| Transcriptional enhancer factor TEF-4 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of His-tagged TEAD2 (unknown origin) preincubated for 0.5 to 4 hrs fo... | 37849539 |
| Transcriptional enhancer factor TEF-5 | IC50 | = | 9.0 | nM | 8.05 | Inhibition of His-tagged TEAD3 (unknown origin) preincubated for 0.5 to 4 hrs fo... | 37849539 |
| Transcriptional enhancer factor TEF-1 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of His-tagged TEAD1 (unknown origin) preincubated for 0.5 to 4 hrs fo... | 37849539 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37849539 | 10.1021/acsmedchemlett.3c00392 | Transcriptional enhancer factor TEF-1 | 1 |
| 37849539 | 10.1021/acsmedchemlett.3c00392 | Transcriptional enhancer factor TEF-4 | 1 |
| 37849539 | 10.1021/acsmedchemlett.3c00392 | Transcriptional enhancer factor TEF-5 | 1 |
| 37849539 | 10.1021/acsmedchemlett.3c00392 | Transcriptional enhancer factor TEF-3 | 1 |
Data from ChEMBL 36 via Core Engine