Assay Detail
Binding
CHEMBL5374065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human parainfluenza virus type 1 Sendai Hemagglutinin-Neuraminidase infected in chicken RBC assessed as reduction in virus-induced hemagglutination of erythrocytes pre incubated for 20 mins followed by addition of chicken erythrocytes measured after 90 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human respirovirus 1 |
| Cell Type | RBC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hemagglutinin-neuraminidase (CHEMBL1764934) ↗| Type | SINGLE PROTEIN |
| Organism | Human parainfluenza virus 1 |
Publication
Interplay of Modified Sialic Acid Inhibitors and the Human Parainfluenza Virus 1 Hemagglutinin-Neuraminidase Active Site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.11 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514002 | — | — | 1 | 7.00 |
| CHEMBL4794921 | — | — | 1 | 6.60 |
| CHEMBL2325808 | — | — | 1 | 5.70 |
| CHEMBL4753314 | — | — | 1 | 5.12 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | - |
| CHEMBL5409811 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514002 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4794921 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2325808 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4753314 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL96712 | NEU5AC2EN | IC50 | > | 10000.0 | nM | - |
| CHEMBL5409811 | — | IC50 | > | 10000.0 | nM | - |