Assay Detail
Binding
CHEMBL5374239
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cy5-labeled p22phox (149 to 162 residues) probe binding to His-tagged human p47phox (151 to 286 residues) expressed in Escherichia coli BL21 (DE3) pLysS incubated for 10 to 15 mins by fluorescence polarization assay
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 69 | 5.33 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410142 | — | — | 1 | 6.62 |
| CHEMBL5427803 | — | — | 1 | 6.38 |
| CHEMBL5411448 | — | — | 1 | 6.36 |
| CHEMBL5406295 | — | — | 1 | 6.33 |
| CHEMBL5412642 | — | — | 1 | 6.30 |
| CHEMBL5419067 | — | — | 1 | 6.22 |
| CHEMBL5410678 | — | — | 1 | 6.19 |
| CHEMBL5413540 | — | — | 1 | 6.17 |
| CHEMBL5437628 | — | — | 1 | 6.01 |
| CHEMBL5411421 | — | — | 1 | 5.91 |
| CHEMBL5398246 | — | — | 1 | 5.91 |
| CHEMBL5439674 | — | — | 1 | 5.89 |
| CHEMBL5438922 | — | — | 1 | 5.88 |
| CHEMBL5439369 | — | — | 1 | 5.87 |
| CHEMBL5426199 | — | — | 1 | 5.80 |
| CHEMBL5433544 | — | — | 1 | 5.79 |
| CHEMBL5429601 | — | — | 1 | 5.75 |
| CHEMBL5422476 | — | — | 1 | 5.74 |
| CHEMBL5399098 | — | — | 1 | 5.73 |
| CHEMBL5406852 | — | — | 1 | 5.71 |
| CHEMBL5425286 | — | — | 1 | 5.66 |
| CHEMBL5414953 | — | — | 1 | 5.59 |
| CHEMBL5437289 | — | — | 1 | 5.55 |
| CHEMBL5436213 | — | — | 1 | 5.53 |
| CHEMBL5432879 | — | — | 1 | 5.50 |
| CHEMBL5421420 | — | — | 1 | 5.47 |
| CHEMBL5438924 | — | — | 1 | 5.44 |
| CHEMBL5425482 | — | — | 1 | 5.44 |
| CHEMBL5404103 | — | — | 1 | 5.43 |
| CHEMBL5414035 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410142 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL5427803 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL5411448 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL5406295 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL5412642 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL5419067 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL5410678 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL5413540 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL5437628 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL5411421 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL5398246 | — | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL5439674 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL5438922 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL5439369 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL5426199 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL5433544 | — | Ki | = | 1640.0 | nM | 5.79 |
| CHEMBL5429601 | — | Ki | = | 1770.0 | nM | 5.75 |
| CHEMBL5422476 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL5399098 | — | Ki | = | 1880.0 | nM | 5.73 |
| CHEMBL5406852 | — | Ki | = | 1930.0 | nM | 5.71 |
| CHEMBL5425286 | — | Ki | = | 2170.0 | nM | 5.66 |
| CHEMBL5414953 | — | Ki | = | 2580.0 | nM | 5.59 |
| CHEMBL5437289 | — | Ki | = | 2840.0 | nM | 5.55 |
| CHEMBL5436213 | — | Ki | = | 2940.0 | nM | 5.53 |
| CHEMBL5432879 | — | Ki | = | 3180.0 | nM | 5.50 |
| CHEMBL5421420 | — | Ki | = | 3370.0 | nM | 5.47 |
| CHEMBL5425482 | — | Ki | = | 3630.0 | nM | 5.44 |
| CHEMBL5438924 | — | Ki | = | 3620.0 | nM | 5.44 |
| CHEMBL5404103 | — | Ki | = | 3740.0 | nM | 5.43 |
| CHEMBL5414035 | — | Ki | = | 4250.0 | nM | 5.37 |
| CHEMBL5437076 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL5421396 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL5416428 | — | Ki | = | 5720.0 | nM | 5.24 |
| CHEMBL5412005 | — | Ki | = | 5920.0 | nM | 5.23 |
| CHEMBL5427003 | — | Ki | = | 6310.0 | nM | 5.20 |
| CHEMBL5440198 | — | Ki | = | 6340.0 | nM | 5.20 |
| CHEMBL5422605 | — | Ki | = | 6390.0 | nM | 5.19 |
| CHEMBL5437700 | — | Ki | = | 6780.0 | nM | 5.17 |
| CHEMBL5399710 | — | Ki | = | 6850.0 | nM | 5.16 |
| CHEMBL5422407 | — | Ki | = | 7580.0 | nM | 5.12 |
| CHEMBL5429761 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL5418747 | — | Ki | = | 9440.0 | nM | 5.03 |
| CHEMBL5400222 | — | Ki | = | 9530.0 | nM | 5.02 |
| CHEMBL5399201 | — | Ki | = | 10100.0 | nM | 5.00 |
| CHEMBL5415338 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL5422943 | — | Ki | = | 10100.0 | nM | 5.00 |
| CHEMBL5407137 | — | Ki | = | 11100.0 | nM | 4.96 |
| CHEMBL5437553 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL5415030 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL5412241 | — | Ki | = | 16800.0 | nM | 4.78 |