Assay Detail
Binding
CHEMBL5374262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NOX-2 dependent superoxide generation in PMA-differentiated human PLB-985 cells incubated for 1 hr by WST-1 based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PLB-985 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.48 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426199 | — | — | 1 | 6.31 |
| CHEMBL5419067 | — | — | 1 | 5.96 |
| CHEMBL5427803 | — | — | 1 | 5.92 |
| CHEMBL5410678 | — | — | 1 | 5.80 |
| CHEMBL5429601 | — | — | 1 | 5.52 |
| CHEMBL5412241 | — | — | 1 | 5.28 |
| CHEMBL5410142 | — | — | 1 | 5.24 |
| CHEMBL5398246 | — | — | 1 | 5.21 |
| CHEMBL5422613 | — | — | 1 | 4.80 |
| CHEMBL5400222 | — | — | 1 | 4.72 |
| CHEMBL5408659 | — | — | 1 | - |
| CHEMBL5411352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426199 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5419067 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5427803 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5410678 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5429601 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5412241 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5410142 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5398246 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5422613 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5400222 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5408659 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL5411352 | — | IC50 | > | 500000.0 | nM | - |