Assay Detail
Binding
CHEMBL5374273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NOX2 (unknown origin) transfected in COS cells assessed as reduction in PMA-stimulated H2O2 production preincubated for 15 mins followed by PMA stimulation and measured for 1 hr by amplex red dye based fluorescence analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.20 | 5.48 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419067 | — | — | 1 | 5.48 |
| CHEMBL5410142 | — | — | 1 | 4.92 |
| CHEMBL5408659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419067 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5410142 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5408659 | — | Inhibition | - | % | - |