Assay Detail
Binding
CHEMBL5374274
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Inhibition of NOX5 (unknown origin) transfected in HEK cells assessed as reduction in PMA/ionomycin-stimulated H2O2 production preincubated for 15 mins followed by PMA /ionomycin stimulation and measured for 1 hr by amplex red dye based fluorescence analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.03 | 4.03 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410142 | — | — | 1 | 4.03 |
| CHEMBL5419067 | — | — | 1 | 4.02 |
| CHEMBL5408659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410142 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL5419067 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL5408659 | — | Inhibition | - | % | - |