Assay Detail
Binding
CHEMBL5374989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Sirt2 (25 to 389 residues) expressed in Escherichia coli BL21(DE3) Codon plus RIPL cells using ZMAL as substrate incubated for 4 hrs in presence of NAD+ by fluorescence based analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.90 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770903 | — | — | 1 | 6.36 |
| CHEMBL3769988 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770903 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3769988 | — | IC50 | = | 3700.0 | nM | 5.43 |