Assay Detail
Binding
CHEMBL5375114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-fused TYK2 (888 to 1187 residues)(unknown origin) using FITC-Ahr-KKSRGDYMTMQIG-NH2 peptide as substrate incubated for 30 mins in presence of ATP by caliper microfluidic mobility shift assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.80 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5412967 | — | — | 1 | 9.00 |
| CHEMBL5396554 | — | — | 1 | 8.70 |
| CHEMBL5407260 | — | — | 1 | 8.70 |
| CHEMBL5404574 | — | — | 1 | 8.70 |
| CHEMBL5422886 | — | — | 1 | 8.70 |
| CHEMBL5407329 | — | — | 1 | 8.15 |
| CHEMBL5431257 | — | — | 1 | 8.00 |
| CHEMBL5409953 | — | — | 1 | 8.00 |
| CHEMBL5403897 | — | — | 1 | 7.77 |
| CHEMBL5420083 | — | — | 1 | 7.68 |
| CHEMBL5424439 | — | — | 1 | 7.54 |
| CHEMBL5417474 | — | — | 1 | 7.43 |
| CHEMBL5270549 | — | — | 1 | 7.30 |
| CHEMBL5395839 | — | — | 1 | 7.27 |
| CHEMBL5279787 | — | — | 1 | 7.23 |
| CHEMBL5420971 | — | — | 1 | 6.77 |
| CHEMBL5271559 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5412967 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5396554 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5407260 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5404574 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5422886 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5407329 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5431257 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5409953 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5403897 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5420083 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5424439 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5417474 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5270549 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5395839 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5279787 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5420971 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5271559 | — | IC50 | = | 2094.0 | nM | 5.68 |