Assay Detail
Functional
CHEMBL5376087
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of ferroptosis in GPX4-dependent human HT-1080 cells assessed as cell viability incubated for 1.5 hrs in presence of 40% human plasma by time-course cell viability assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis <i>In Vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.88 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428657 | — | — | 1 | 5.90 |
| CHEMBL4747331 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428657 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4747331 | — | EC50 | = | 1420.0 | nM | 5.85 |