Assay Detail
Binding
CHEMBL5376115
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Agonist activity at MRGPRX4 83L (unknown origin) expressed in HEK293 cells co-expressing Gq assessed as change in intracellular calcium level by FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.81 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5402204 | — | — | 1 | 6.83 |
| CHEMBL5403433 | — | — | 1 | 6.24 |
| CHEMBL783 | NATEGLINIDE | 4.0 | 1 | 5.33 |
| CHEMBL412272 | TAURODEOXYCHOLIC ACID | 2.0 | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5402204 | — | EC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5403433 | — | EC50 | = | 581.0 | nM | 6.24 |
| CHEMBL783 | NATEGLINIDE | EC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL412272 | TAURODEOXYCHOLIC ACID | EC50 | = | 14100.0 | nM | 4.85 |