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Compound Detail

CHEMBL5402204

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C[C@]12C[C@@H]3C[C@](C)(C1)C[C@@](C(=O)N[C@H](Cc1ccccc1)C(=O)O)(C3)C2

Basic Information

ChEMBL ID CHEMBL5402204
Phase Preclinical
Structure Type MOL
InChI Key QSBRCNGPJBWGLQ-LQDXOGNASA-N
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

355.5
MW (Da)
3.80
ALogP
2
HBA
2
HBD
66.4
PSA (Ų)
0.84
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H29NO3
MW 355.48
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness -0.15

Activity Summary

EC50 5 meas. best 8.18

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 8.18 6.31 6.6 5

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
37967029 10.1021/acs.jmedchem.3c01013 Unchecked 6

Data from ChEMBL 36 via Core Engine