Assay Detail
Binding
CHEMBL5376137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.26 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456922 | — | — | 1 | 6.40 |
| CHEMBL5416784 | — | — | 1 | 6.30 |
| CHEMBL5420656 | — | — | 1 | 6.30 |
| CHEMBL5432176 | — | — | 1 | 6.20 |
| CHEMBL5409942 | — | — | 1 | 5.90 |
| CHEMBL5414030 | — | — | 1 | 5.60 |
| CHEMBL5411322 | — | — | 1 | 5.40 |
| CHEMBL5416283 | — | — | 1 | 5.30 |
| CHEMBL5440431 | — | — | 1 | 5.10 |
| CHEMBL5421774 | — | — | 1 | 5.10 |
| CHEMBL5400900 | — | — | 1 | 5.00 |
| CHEMBL5413795 | — | — | 1 | 5.00 |
| CHEMBL5395952 | — | — | 1 | 4.90 |
| CHEMBL5425663 | — | — | 1 | 4.90 |
| CHEMBL5413916 | — | — | 1 | 4.80 |
| CHEMBL5405343 | — | — | 1 | 4.80 |
| CHEMBL5439597 | — | — | 1 | 4.70 |
| CHEMBL5437203 | — | — | 1 | 4.70 |
| CHEMBL5394124 | — | — | 1 | 4.70 |
| CHEMBL5395658 | — | — | 1 | 4.70 |
| CHEMBL5418662 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456922 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5416784 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5420656 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5432176 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL5409942 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL5414030 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL5411322 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL5416283 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL5440431 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL5421774 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL5400900 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5413795 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5395952 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL5425663 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL5413916 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL5405343 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL5439597 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL5437203 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL5394124 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL5395658 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL5418662 | — | IC50 | = | 19952.62 | nM | 4.70 |