Assay Detail
Functional
CHEMBL5376804
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.07 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 8.40 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.39 |
| CHEMBL4577077 | — | — | 1 | 6.24 |
| CHEMBL5412066 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4577077 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5412066 | — | EC50 | = | 580.0 | nM | 6.24 |