Assay Detail
Toxicity
CHEMBL5377330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of apoptosis in human HEK293 cells incubated for 24 hrs by annexin V/PI staining based flow cytometry analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploiting the "Hot-Spots" of Hsp70<b>-</b>Bim Protein<b>-</b>Protein Interaction to Optimize the 1-Oxo-1<i>H</i>-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70<b>-</b>Bim Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.11 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470334 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470334 | — | EC50 | = | 7700.0 | nM | 5.11 |