Assay Detail
ADMET
CHEMBL5377830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant CYP1A2 (unknown origin) using 7-ethoxyresorufin as substrate preincubated for 5 mins followed by NADPH addition incubated for 50 mins by EROD assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of Novel Near-Infrared Fluorescence Probes Based on an Open Conformation of a Cytochrome P450 1B1 Complex for Molecular Imaging of Colorectal Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.34 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 8.12 |
| CHEMBL5435493 | — | — | 1 | 6.29 |
| CHEMBL5418796 | — | — | 1 | 6.28 |
| CHEMBL5396845 | — | — | 1 | 5.83 |
| CHEMBL5426998 | — | — | 1 | 5.80 |
| CHEMBL5426732 | — | — | 1 | 5.73 |
| CHEMBL5422312 | — | — | 1 | - |
| CHEMBL5421843 | — | — | 1 | - |
| CHEMBL5429019 | — | — | 1 | - |
| CHEMBL5405256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 7.67 | nM | 8.12 |
| CHEMBL5435493 | — | IC50 | = | 513.9 | nM | 6.29 |
| CHEMBL5418796 | — | IC50 | = | 524.57 | nM | 6.28 |
| CHEMBL5396845 | — | IC50 | = | 1463.33 | nM | 5.83 |
| CHEMBL5426998 | — | IC50 | = | 1598.33 | nM | 5.80 |
| CHEMBL5426732 | — | IC50 | = | 1844.33 | nM | 5.73 |
| CHEMBL5422312 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5421843 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5429019 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5405256 | — | IC50 | > | 2000.0 | nM | - |