Assay Detail
Binding
CHEMBL5377861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant TYK2 (unknown origin) using GFP-STAT1 as substrate incubated for 1 hr by TR-FRET Lanthascreen assay
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.96 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5396523 | — | — | 1 | 8.07 |
| CHEMBL5423944 | — | — | 1 | 8.03 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 7.91 |
| CHEMBL5427932 | — | — | 1 | 7.88 |
| CHEMBL5408324 | — | — | 1 | 7.78 |
| CHEMBL5410919 | — | — | 1 | 7.50 |
| CHEMBL5435417 | — | — | 1 | 7.43 |
| CHEMBL5402123 | — | — | 1 | 7.41 |
| CHEMBL5398372 | — | — | 2 | 7.39 |
| CHEMBL5440017 | — | — | 1 | 7.35 |
| CHEMBL5430795 | — | — | 1 | 7.24 |
| CHEMBL5397297 | — | — | 1 | 7.23 |
| CHEMBL5405043 | — | — | 1 | 7.13 |
| CHEMBL5423894 | — | — | 1 | 7.12 |
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 6.95 |
| CHEMBL5405140 | — | — | 1 | 6.91 |
| CHEMBL5423387 | — | — | 1 | 6.62 |
| CHEMBL5441087 | — | — | 1 | 6.45 |
| CHEMBL5420407 | — | — | 1 | 6.40 |
| CHEMBL5410927 | — | — | 1 | 6.38 |
| CHEMBL5439582 | — | — | 1 | 6.34 |
| CHEMBL4742766 | — | — | 1 | 6.31 |
| CHEMBL5434116 | — | — | 1 | 6.23 |
| CHEMBL5430831 | — | — | 1 | 5.97 |
| CHEMBL5400756 | — | — | 1 | 5.97 |
| CHEMBL5404261 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5396523 | — | IC50 | = | 8.42 | nM | 8.07 |
| CHEMBL5423944 | — | IC50 | = | 9.32 | nM | 8.03 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL5427932 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL5408324 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5410919 | — | IC50 | = | 31.6 | nM | 7.50 |
| CHEMBL5435417 | — | IC50 | = | 36.9 | nM | 7.43 |
| CHEMBL5402123 | — | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL5398372 | — | IC50 | = | 40.3 | nM | 7.39 |
| CHEMBL5440017 | — | IC50 | = | 44.9 | nM | 7.35 |
| CHEMBL5430795 | — | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL5397297 | — | IC50 | = | 58.3 | nM | 7.23 |
| CHEMBL5405043 | — | IC50 | = | 74.9 | nM | 7.13 |
| CHEMBL5423894 | — | IC50 | = | 75.9 | nM | 7.12 |
| CHEMBL3301607 | FILGOTINIB | IC50 | = | 111.7 | nM | 6.95 |
| CHEMBL5405140 | — | IC50 | = | 123.4 | nM | 6.91 |
| CHEMBL5423387 | — | IC50 | = | 239.2 | nM | 6.62 |
| CHEMBL5441087 | — | IC50 | = | 357.6 | nM | 6.45 |
| CHEMBL5420407 | — | IC50 | = | 395.5 | nM | 6.40 |
| CHEMBL5410927 | — | IC50 | = | 411.9 | nM | 6.38 |
| CHEMBL5439582 | — | IC50 | = | 458.5 | nM | 6.34 |
| CHEMBL4742766 | — | IC50 | = | 493.2 | nM | 6.31 |
| CHEMBL5434116 | — | IC50 | = | 593.1 | nM | 6.23 |
| CHEMBL5398372 | — | IC50 | = | 788.6 | nM | 6.10 |
| CHEMBL5430831 | — | IC50 | = | 1069.5 | nM | 5.97 |
| CHEMBL5400756 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5404261 | — | IC50 | = | 1124.9 | nM | 5.95 |