Assay Detail
Binding
CHEMBL5377990
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of STAT5 phosphorylation in human SK-MES-1 cells pretreated for 30 mins followed by GM-CSF stimulation by Western blot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-MES-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 5A (CHEMBL5403) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and Biological Evaluation of a Potent and Selective JAK1 Inhibitor for the Treatment of Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.40 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397297 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397297 | — | EC50 | = | 40.0 | nM | 7.40 |