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Assay Detail

CHEMBL5378339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of His6-tagged KIND2 (unknown origin) expressed in Escherichia coli BL21(DE3) by fluorescence polarization method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fermitin family homolog 2 (CHEMBL5465266)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Inhibitory Fragments That Selectively Target Spire2-FMN2 Interaction.
Kitel R, Surmiak E, Borggräfe J, Kalinowska-Tluscik J, Golik P, Czub M, Uzar W, Musielak B, Madej M, Popowicz GM, Dubin G, Holak TA.
J Med Chem (2023) 66 : 15715 -15727
PubMed 38039505 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 3.55 4.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5394576 1 4.21
CHEMBL2393341 1 3.99
CHEMBL99254 1 3.57
CHEMBL236491 1 3.44
CHEMBL316953 1 3.35
CHEMBL235241 1 3.25
CHEMBL581588 1 3.03
CHEMBL460418 1 -
CHEMBL44789 1 -
CHEMBL1241726 1 -
CHEMBL236696 1 -
CHEMBL31000 1 -
CHEMBL98114 1 -
CHEMBL5414257 1 -
CHEMBL5426817 1 -
CHEMBL5414970 1 -
CHEMBL5414019 1 -
CHEMBL5403742 1 -
CHEMBL5414961 1 -
CHEMBL2393338 1 -
CHEMBL2393337 1 -
CHEMBL5399645 1 -
CHEMBL5403660 1 -
CHEMBL5402421 1 -
CHEMBL5430068 1 -
CHEMBL5407372 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5394576 IC50 = 62000.0 nM 4.21
CHEMBL2393341 IC50 = 103000.0 nM 3.99
CHEMBL99254 IC50 = 268000.0 nM 3.57
CHEMBL236491 IC50 = 362000.0 nM 3.44
CHEMBL316953 IC50 = 448000.0 nM 3.35
CHEMBL235241 IC50 = 565000.0 nM 3.25
CHEMBL581588 IC50 = 938000.0 nM 3.03
CHEMBL460418 IC50 > 2500000.0 nM -
CHEMBL44789 IC50 > 2500000.0 nM -
CHEMBL1241726 IC50 > 2500000.0 nM -
CHEMBL236696 IC50 > 2500000.0 nM -
CHEMBL31000 IC50 > 2500000.0 nM -
CHEMBL98114 IC50 > 2500000.0 nM -
CHEMBL5414257 IC50 > 2500000.0 nM -
CHEMBL5426817 IC50 > 2500000.0 nM -
CHEMBL5414970 IC50 > 2500000.0 nM -
CHEMBL5414019 IC50 > 2500000.0 nM -
CHEMBL5403742 IC50 > 2500000.0 nM -
CHEMBL5414961 IC50 > 2500000.0 nM -
CHEMBL2393338 IC50 > 2500000.0 nM -
CHEMBL2393337 IC50 > 2500000.0 nM -
CHEMBL5399645 IC50 > 2500000.0 nM -
CHEMBL5403660 IC50 > 2500000.0 nM -
CHEMBL5402421 IC50 > 2500000.0 nM -
CHEMBL5430068 IC50 > 2500000.0 nM -
CHEMBL5407372 IC50 > 2500000.0 nM -