Assay Detail
Functional
CHEMBL5378739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cells harboring p53 assessed inhibition of cell growth incubated for 4 days by CCK-8 assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.09 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404903 | — | — | 1 | 8.89 |
| CHEMBL5424005 | — | — | 1 | 8.82 |
| CHEMBL5405147 | — | — | 1 | 8.44 |
| CHEMBL5436246 | — | — | 1 | 8.31 |
| CHEMBL5402394 | — | — | 1 | 8.27 |
| CHEMBL5433398 | — | — | 1 | 8.00 |
| CHEMBL5395046 | — | — | 1 | 7.96 |
| CHEMBL5413376 | — | — | 1 | 7.96 |
| CHEMBL5440363 | — | — | 1 | 7.66 |
| CHEMBL5405392 | — | — | 1 | 7.66 |
| CHEMBL5431530 | — | — | 1 | 7.59 |
| CHEMBL5405110 | — | — | 1 | 7.51 |
| CHEMBL5397752 | — | — | 1 | 7.49 |
| CHEMBL5403772 | — | — | 1 | 7.43 |
| CHEMBL5441014 | — | — | 1 | 7.37 |
| CHEMBL5414460 | — | — | 1 | 7.29 |
| CHEMBL5436528 | — | — | 1 | 7.12 |
| CHEMBL5396046 | — | — | 1 | 6.99 |
| CHEMBL5421232 | — | — | 1 | 6.86 |
| CHEMBL5406959 | — | — | 1 | 6.84 |
| CHEMBL5398827 | — | — | 1 | 6.83 |
| CHEMBL5438528 | — | — | 1 | 6.50 |
| CHEMBL5404372 | — | — | 1 | 6.25 |
| CHEMBL5423725 | — | — | 1 | 6.25 |
| CHEMBL5400878 | — | — | 1 | 6.18 |
| CHEMBL5403609 | — | — | 1 | 6.06 |
| CHEMBL5408617 | — | — | 1 | 6.03 |
| CHEMBL5401273 | — | — | 1 | 6.02 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 5.98 |
| CHEMBL5437702 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404903 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5424005 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5405147 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5436246 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5402394 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5433398 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5395046 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5413376 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5440363 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5405392 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL5431530 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL5405110 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5397752 | — | IC50 | = | 32.7 | nM | 7.49 |
| CHEMBL5403772 | — | IC50 | = | 37.3 | nM | 7.43 |
| CHEMBL5441014 | — | IC50 | = | 42.3 | nM | 7.37 |
| CHEMBL5414460 | — | IC50 | = | 51.7 | nM | 7.29 |
| CHEMBL5436528 | — | IC50 | = | 75.5 | nM | 7.12 |
| CHEMBL5396046 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5421232 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL5406959 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL5398827 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5438528 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL5404372 | — | IC50 | = | 558.0 | nM | 6.25 |
| CHEMBL5423725 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL5400878 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL5403609 | — | IC50 | = | 865.0 | nM | 6.06 |
| CHEMBL5408617 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL5401273 | — | IC50 | = | 951.0 | nM | 6.02 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 1038.0 | nM | 5.98 |
| CHEMBL5437702 | — | IC50 | = | 1043.0 | nM | 5.98 |
| CHEMBL5423147 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5411556 | — | IC50 | = | 1559.0 | nM | 5.81 |
| CHEMBL5394717 | — | IC50 | = | 2038.0 | nM | 5.69 |