Assay Detail
Functional
CHEMBL5378740
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human RKO cells harboring p53 assessed inhibition of cell growth incubated for 4 days by CCK-8 assay
38
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RKO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.26 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407963 | — | — | 1 | 7.89 |
| CHEMBL5405880 | — | — | 1 | 7.61 |
| CHEMBL5425989 | — | — | 2 | 7.37 |
| CHEMBL5404903 | — | — | 1 | 7.17 |
| CHEMBL5436246 | — | — | 1 | 7.08 |
| CHEMBL5424005 | — | — | 1 | 6.90 |
| CHEMBL5413376 | — | — | 1 | 6.86 |
| CHEMBL5438520 | — | — | 1 | 6.84 |
| CHEMBL5431530 | — | — | 1 | 6.76 |
| CHEMBL5405147 | — | — | 1 | 6.66 |
| CHEMBL5395046 | — | — | 1 | 6.62 |
| CHEMBL5440363 | — | — | 1 | 6.61 |
| CHEMBL5402394 | — | — | 1 | 6.59 |
| CHEMBL5436528 | — | — | 1 | 6.48 |
| CHEMBL5397752 | — | — | 1 | 6.46 |
| CHEMBL5403772 | — | — | 1 | 6.45 |
| CHEMBL5405392 | — | — | 1 | 6.39 |
| CHEMBL5405110 | — | — | 1 | 6.39 |
| CHEMBL5441014 | — | — | 1 | 6.36 |
| CHEMBL5433398 | — | — | 1 | 6.36 |
| CHEMBL5414460 | — | — | 1 | 6.22 |
| CHEMBL5398827 | — | — | 1 | 6.04 |
| CHEMBL5421232 | — | — | 1 | 6.00 |
| CHEMBL5406959 | — | — | 1 | 5.99 |
| CHEMBL5396046 | — | — | 1 | 5.94 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 5.72 |
| CHEMBL5400878 | — | — | 1 | 5.70 |
| CHEMBL5438528 | — | — | 1 | 5.62 |
| CHEMBL5403609 | — | — | 1 | 5.53 |
| CHEMBL5423147 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407963 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL5405880 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL5425989 | — | IC50 | = | 43.2 | nM | 7.37 |
| CHEMBL5404903 | — | IC50 | = | 66.9 | nM | 7.17 |
| CHEMBL5436246 | — | IC50 | = | 82.4 | nM | 7.08 |
| CHEMBL5425989 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5424005 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL5413376 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL5438520 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL5431530 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL5405147 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL5395046 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL5440363 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5402394 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL5436528 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5397752 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL5403772 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL5405392 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL5405110 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL5433398 | — | IC50 | = | 436.0 | nM | 6.36 |
| CHEMBL5441014 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5414460 | — | IC50 | = | 602.0 | nM | 6.22 |
| CHEMBL5398827 | — | IC50 | = | 901.0 | nM | 6.04 |
| CHEMBL5421232 | — | IC50 | = | 1007.0 | nM | 6.00 |
| CHEMBL5406959 | — | IC50 | = | 1014.0 | nM | 5.99 |
| CHEMBL5396046 | — | IC50 | = | 1149.0 | nM | 5.94 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 1917.0 | nM | 5.72 |
| CHEMBL5400878 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL5438528 | — | IC50 | = | 2393.0 | nM | 5.62 |
| CHEMBL5403609 | — | IC50 | = | 2942.0 | nM | 5.53 |
| CHEMBL5423147 | — | IC50 | = | 4434.0 | nM | 5.35 |
| CHEMBL5401273 | — | IC50 | = | 4585.0 | nM | 5.34 |
| CHEMBL5423725 | — | IC50 | = | 4523.0 | nM | 5.34 |
| CHEMBL5394717 | — | IC50 | = | 5235.0 | nM | 5.28 |
| CHEMBL5408617 | — | IC50 | = | 5225.0 | nM | 5.28 |
| CHEMBL5437702 | — | IC50 | = | 5487.0 | nM | 5.26 |
| CHEMBL5411556 | — | IC50 | = | 5899.0 | nM | 5.23 |
| CHEMBL5404372 | — | IC50 | = | 5952.0 | nM | 5.22 |