Assay Detail
Toxicity
CHEMBL5378753
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Antiproliferative activity against HEK293 cells harboring p53 assessed inhibition of cell growth incubated for 4 days by CCK-8 assay
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.35 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397752 | — | — | 1 | 5.44 |
| CHEMBL5425989 | — | — | 2 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397752 | — | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL5425989 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL5425989 | — | IC50 | = | 5940.0 | nM | 5.23 |