Assay Detail
Binding
CHEMBL5378940
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Agonist activity at full length human RXR gamma expressed in HEK293T cells measured after 16 hrs by Dual-glo luciferase assay
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Fusion of Natural and Synthetic Ligand Features Boosts RXR Agonist Potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.08 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404648 | — | — | 2 | 9.22 |
| CHEMBL5412777 | — | — | 1 | 7.77 |
| CHEMBL5407623 | — | — | 1 | 7.64 |
| CHEMBL5436895 | — | — | 1 | 7.24 |
| CHEMBL5399947 | — | — | 1 | 5.66 |
| CHEMBL5394779 | — | — | 1 | 5.47 |
| CHEMBL5395851 | — | — | 1 | 5.24 |
| CHEMBL5423123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404648 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5404648 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5412777 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5407623 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5436895 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5399947 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5394779 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5395851 | — | EC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL5423123 | — | EC50 | > | 10000.0 | nM | - |