Assay Detail
Functional
CHEMBL5380296
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Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 2 to 4 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.22 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5432408 | — | — | 1 | 7.05 |
| CHEMBL5437417 | — | — | 1 | 7.00 |
| CHEMBL5436786 | — | — | 1 | 6.46 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.23 |
| CHEMBL5413498 | — | — | 1 | 6.11 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 5.58 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5432408 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5437417 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5436786 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5413498 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 7380.0 | nM | 5.13 |