Assay Detail
Binding
CHEMBL5380299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of novel morpholinopyrimidine-5-carbonitrile derivatives as dual PI3K/mTOR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.88 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5437417 | — | — | 1 | 6.89 |
| CHEMBL5432408 | — | — | 1 | 5.50 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5437417 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5432408 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL98350 | LY-294002 | IC50 | = | 5430.0 | nM | 5.26 |