Assay Detail
Binding
CHEMBL5380325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR-2 (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 5 mins by ELISA method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Role of heterocycles in inhibition of VEGFR-2 - a recent update (2019-2022).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.94 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5427272 | — | — | 1 | 5.96 |
| CHEMBL5404662 | — | — | 1 | 5.92 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5427272 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5404662 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 1270.0 | nM | - |