Compound Detail
CHEMBL5404662
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Basic Information
| ChEMBL ID | CHEMBL5404662 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JTMLGYOZNRPPEA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
471.5
MW (Da)
2.12
ALogP
7
HBA
4
HBD
142.4
PSA (Ų)
0.33
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.92 | 5.92 | 1190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1190.0 | nM | 5.92 | Inhibition of VEGFR-2 (unknown origin) kinase activity using poly(Glu-Tyr) at 4:... | 38389872 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38389872 | 10.1039/d3md00506b | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine