Assay Detail
Binding
CHEMBL5380377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged human recombinant wild type TRKA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Kinase inhibitor macrocycles: a perspective on limiting conformational flexibility when targeting the kinome with small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.18 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5400169 | — | — | 1 | 9.27 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 9.22 |
| CHEMBL3889654 | LAROTRECTINIB | 4.0 | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5400169 | — | IC50 | = | 0.533 | nM | 9.27 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3889654 | LAROTRECTINIB | IC50 | = | 0.9 | nM | 9.05 |