Assay Detail
Binding
CHEMBL5380716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of c-kit (unknown origin) using peptide substrate incubated for 1 hrs in presence of ATP by fluorescence microplate reader analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.27 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 7.08 |
| CHEMBL5406425 | — | — | 1 | 5.01 |
| CHEMBL5401267 | — | — | 1 | 4.98 |
| CHEMBL5428278 | — | — | 1 | 4.96 |
| CHEMBL5408027 | — | — | 1 | 4.91 |
| CHEMBL5411672 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 82.63 | nM | 7.08 |
| CHEMBL5406425 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL5401267 | — | IC50 | = | 10497.5 | nM | 4.98 |
| CHEMBL5428278 | — | IC50 | = | 10887.5 | nM | 4.96 |
| CHEMBL5408027 | — | IC50 | = | 12269.0 | nM | 4.91 |
| CHEMBL5411672 | — | IC50 | = | 21348.5 | nM | 4.67 |