Assay Detail
Binding
CHEMBL5381507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PEPD using Ala-Pro as substrate assessed as alanine release by measuring increase in fluorescense signal by fluorescence based analysis
48
Total Activities
48
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.59 | 6.55 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419166 | — | — | 1 | 6.55 |
| CHEMBL5433567 | — | — | 1 | 6.54 |
| CHEMBL5435351 | — | — | 1 | 6.52 |
| CHEMBL5429139 | — | — | 1 | 6.28 |
| CHEMBL5433668 | — | — | 1 | 6.25 |
| CHEMBL5437413 | — | — | 1 | 6.17 |
| CHEMBL5419034 | — | — | 1 | 6.14 |
| CHEMBL5393876 | — | — | 1 | 6.14 |
| CHEMBL5401781 | — | — | 1 | 6.08 |
| CHEMBL5407130 | — | — | 1 | 6.08 |
| CHEMBL5410658 | — | — | 1 | 6.04 |
| CHEMBL5403940 | — | — | 1 | 6.00 |
| CHEMBL5399924 | — | — | 1 | 5.92 |
| CHEMBL5396150 | — | — | 1 | 5.89 |
| CHEMBL5438777 | — | — | 1 | 5.82 |
| CHEMBL5436435 | — | — | 1 | 5.82 |
| CHEMBL5396773 | — | — | 1 | 5.80 |
| CHEMBL5398054 | — | — | 1 | 5.77 |
| CHEMBL5421036 | — | — | 1 | 5.75 |
| CHEMBL5394915 | — | — | 1 | 5.75 |
| CHEMBL5404330 | — | — | 1 | 5.70 |
| CHEMBL5433606 | — | — | 1 | 5.66 |
| CHEMBL5406619 | — | — | 1 | 5.55 |
| CHEMBL5419938 | — | — | 1 | 5.43 |
| CHEMBL5430934 | — | — | 1 | 5.40 |
| CHEMBL5403929 | — | — | 1 | 5.38 |
| CHEMBL5400780 | — | — | 1 | 5.24 |
| CHEMBL5432938 | — | — | 1 | 5.21 |
| CHEMBL5403681 | — | — | 1 | 5.12 |
| CHEMBL5403523 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419166 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5433567 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5435351 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5429139 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5433668 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5437413 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL5419034 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5393876 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5401781 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL5407130 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL5410658 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5403940 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5399924 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5396150 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5436435 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5438777 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5396773 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5398054 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5421036 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5394915 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5404330 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5433606 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5406619 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5419938 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5430934 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5403929 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5400780 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL5432938 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5403681 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL5403523 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5438224 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL5402862 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5435178 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5409645 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5419889 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5397935 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL311875 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5415840 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL5427035 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL5424113 | — | Inhibition | - | % | - | |
| CHEMBL5408940 | — | Inhibition | - | % | - | |
| CHEMBL5426465 | — | Inhibition | - | % | - | |
| CHEMBL67279 | TALABOSTAT | IC50 | ~ | 10000.0 | nM | - |
| CHEMBL5412812 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5421582 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5415378 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL457092 | BESTATIN METHYL ESTER | IC50 | > | 100000.0 | nM | - |
| CHEMBL5412099 | — | IC50 | > | 100000.0 | nM | - |