Xaa-Pro dipeptidase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P12955. Use UniProt P12955 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P12955 as the stable identity anchor, then attach disease evidence before program review.
Xaa-Pro dipeptidase
Review this target as Xaa-Pro dipeptidase, mapped to UniProt P12955. Sequence length is 493 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Xaa-Pro dipeptidase as ChEMBL target CHEMBL4185, mapped to UniProt P12955. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Xaa-Pro dipeptidase is the right protein anchor across sources, using UniProt P12955 as the stable mapping.
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| Preferred Name | Xaa-Pro dipeptidase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P12955 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Xaa-Pro dipeptidase |
| UniProt Accession | P12955 |
| Component Type | Protein |
| Sequence Length | 493 aa |
Xaa-Pro dipeptidase
Review this target as Xaa-Pro dipeptidase, mapped to UniProt P12955. Sequence length is 493 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1235228 | 8.07 | Ki | 8.5 | Preclinical |
| CHEMBL96505 | 6.57 | Ki | 270.0 | Preclinical |
| CHEMBL5419166 | 6.55 | IC50 | 280.0 | Preclinical |
| CHEMBL5433567 | 6.54 | IC50 | 290.0 | Preclinical |
| CHEMBL178 | 6.52 | IC50 | 300.0 | Approved |
| CHEMBL5435351 | 6.52 | IC50 | 300.0 | Preclinical |
| CHEMBL5429139 | 6.28 | IC50 | 530.0 | Preclinical |
| CHEMBL5653589 | 6.26 | Kd | 547.31 | Preclinical |
| CHEMBL5433668 | 6.25 | IC50 | 560.0 | Preclinical |
| CHEMBL2369858 | 6.18 | IC50 | 660.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 26 | 57 | 5.6 |
| cell-based format | 5 | 1 | 5.0 |