Assay Detail

CHEMBL5381640

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Toxicity

Binding affinity to urotensin 2 receptor (unknown origin)

ChEMBL ↗

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Target

Urotensin-2 receptor (CHEMBL3764) ↗

Open DB target context

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Urotensin-2 receptor (CHEMBL3764) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Urotensin-2 receptor

CHEMBL3764

Anchored from Assay target.

Protein identity Urotensin-2 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Toxicity
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Urotensin-2 receptor (CHEMBL3764) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.

Scott JS, Stead D, Barlaam B, Breed J, Carbajo RJ, Chiarparin E, Cureton N, Davey PRJ, Fisher DI, Gangl ET, Grebe T, Greenwood RD, Hande S, Hatoum-Mokdad H, Hughes SJ, Hunt TA, Johnson T, Kavanagh SL, Klinowska TCM, Larner CJB, Lawson M, Lister AS, Longmire D, Marden S, McGuire TM, McMillan C, McMurray L, Morrow CJ, Nissink JWM, Moss TA, O'Donovan DH, Polanski R, Stokes S, Thakur K, Trueman D, Truman C, Tucker MJ, Wang H, Whalley N, Wu D, Wu Y, Yang B, Yang W.
J Med Chem (2023) 66 : 2918 -2945
PubMed 36727211 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	5.11	5.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5426983	—	—	1	5.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5426983	—	Ki	=	7700.0	nM	5.11