Assay Detail
Functional
CHEMBL5381802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of vinorelbine resistance in human KBv200 cells assessed as reduction in cell viability incubated for 72 hrs in presence of vinorelbine (Rvb = 224 to 228.30 nM)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KBv200 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modular Biomimetic Strategy Enabled Discovery of Simplified Pseudo-Natural Macrocyclic P-Glycoprotein Inhibitors Capable of Overcoming Multidrug Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 8.32 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399206 | — | — | 1 | 10.70 |
| CHEMBL5399548 | — | — | 1 | 10.30 |
| CHEMBL5440498 | — | — | 1 | 9.68 |
| CHEMBL5405970 | — | — | 1 | 9.52 |
| CHEMBL5411100 | — | — | 1 | 9.42 |
| CHEMBL5438378 | — | — | 1 | 9.40 |
| CHEMBL5401184 | — | — | 1 | 9.38 |
| CHEMBL5414613 | — | — | 1 | 9.36 |
| CHEMBL5412964 | — | — | 1 | 9.26 |
| CHEMBL5437817 | — | — | 1 | 9.13 |
| CHEMBL5423696 | — | — | 1 | 8.95 |
| CHEMBL5400937 | — | — | 1 | 8.92 |
| CHEMBL5424930 | — | — | 1 | 8.91 |
| CHEMBL5415612 | — | — | 1 | 8.81 |
| CHEMBL5436836 | — | — | 1 | 8.75 |
| CHEMBL5409040 | — | — | 1 | 8.45 |
| CHEMBL5440933 | — | — | 1 | 8.44 |
| CHEMBL5394735 | — | — | 1 | 8.44 |
| CHEMBL5422705 | — | — | 1 | 8.43 |
| CHEMBL5401230 | — | — | 1 | 8.34 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 8.16 |
| CHEMBL5427928 | — | — | 1 | 8.06 |
| CHEMBL5394304 | — | — | 1 | 7.61 |
| CHEMBL5424931 | — | — | 1 | 7.33 |
| CHEMBL5422663 | — | — | 1 | 6.90 |
| CHEMBL5439986 | — | — | 1 | 6.85 |
| CHEMBL5418928 | — | — | 1 | 6.85 |
| CHEMBL5419588 | — | — | 1 | 6.82 |
| CHEMBL5436774 | — | — | 1 | 6.77 |
| CHEMBL5430656 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399206 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL5399548 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL5440498 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL5405970 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5411100 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL5438378 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5401184 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL5414613 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL5412964 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL5437817 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL5423696 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL5400937 | — | IC50 | = | 1.19 | nM | 8.92 |
| CHEMBL5424930 | — | IC50 | = | 1.24 | nM | 8.91 |
| CHEMBL5415612 | — | IC50 | = | 1.54 | nM | 8.81 |
| CHEMBL5436836 | — | IC50 | = | 1.76 | nM | 8.75 |
| CHEMBL5409040 | — | IC50 | = | 3.58 | nM | 8.45 |
| CHEMBL5440933 | — | IC50 | = | 3.65 | nM | 8.44 |
| CHEMBL5394735 | — | IC50 | = | 3.64 | nM | 8.44 |
| CHEMBL5422705 | — | IC50 | = | 3.76 | nM | 8.43 |
| CHEMBL5401230 | — | IC50 | = | 4.57 | nM | 8.34 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 6.96 | nM | 8.16 |
| CHEMBL5427928 | — | IC50 | = | 8.63 | nM | 8.06 |
| CHEMBL5394304 | — | IC50 | = | 24.48 | nM | 7.61 |
| CHEMBL5424931 | — | IC50 | = | 46.64 | nM | 7.33 |
| CHEMBL5422663 | — | IC50 | = | 126.6 | nM | 6.90 |
| CHEMBL5439986 | — | IC50 | = | 139.9 | nM | 6.85 |
| CHEMBL5418928 | — | IC50 | = | 140.4 | nM | 6.85 |
| CHEMBL5419588 | — | IC50 | = | 152.3 | nM | 6.82 |
| CHEMBL5436774 | — | IC50 | = | 169.4 | nM | 6.77 |
| CHEMBL5430656 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL5408442 | — | IC50 | = | 209.5 | nM | 6.68 |
| CHEMBL5440594 | — | IC50 | = | 247.8 | nM | 6.61 |
| CHEMBL5433471 | — | IC50 | = | 289.2 | nM | 6.54 |