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Assay Detail

CHEMBL5382952

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity in human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type WI-38
Confidence 1 — Organism
Curated By Autocuration

Target

WI-38 (CHEMBL614391)
Type CELL-LINE
Organism Homo sapiens

Publication

Inclusion of Nitrofurantoin into the Realm of Cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing.
Elzahhar PA, Nematalla HA, Al-Koussa H, Abrahamian C, El-Yazbi AF, Bodgi L, Bou-Gharios J, Azzi J, Al Choboq J, Labib HF, Kheir WA, Abu-Serie MM, Elrewiny MA, El-Yazbi AF, Belal ASF.
J Med Chem (2023) 66 : 4565 -4587
PubMed 36921275 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.67 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5409734 1 6.92
CHEMBL5418979 1 6.85
CHEMBL5397378 1 6.82
CHEMBL572 NITROFURANTOIN 4.0 1 6.79
CHEMBL5395379 1 6.75
CHEMBL5402742 1 6.74
CHEMBL5417587 1 6.74
CHEMBL185 FLUOROURACIL 4.0 1 6.72
CHEMBL5414232 1 6.67
CHEMBL5426678 1 6.66
CHEMBL5416478 1 6.65
CHEMBL5423492 1 6.63
CHEMBL5433427 1 6.62
CHEMBL5398658 1 6.60
CHEMBL5439883 1 6.60
CHEMBL5402001 1 6.51
CHEMBL5416201 1 6.06

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5409734 IC50 = 119.0 nM 6.92
CHEMBL5418979 IC50 = 140.0 nM 6.85
CHEMBL5397378 IC50 = 150.0 nM 6.82
CHEMBL572 NITROFURANTOIN IC50 = 162.0 nM 6.79
CHEMBL5395379 IC50 = 180.0 nM 6.75
CHEMBL5402742 IC50 = 183.0 nM 6.74
CHEMBL5417587 IC50 = 181.0 nM 6.74
CHEMBL185 FLUOROURACIL IC50 = 192.0 nM 6.72
CHEMBL5414232 IC50 = 216.0 nM 6.67
CHEMBL5426678 IC50 = 220.0 nM 6.66
CHEMBL5416478 IC50 = 226.0 nM 6.65
CHEMBL5423492 IC50 = 232.0 nM 6.63
CHEMBL5433427 IC50 = 240.0 nM 6.62
CHEMBL5398658 IC50 = 251.0 nM 6.60
CHEMBL5439883 IC50 = 249.0 nM 6.60
CHEMBL5402001 IC50 = 306.0 nM 6.51
CHEMBL5416201 IC50 = 879.0 nM 6.06