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Assay Detail

CHEMBL5383368

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Functional
Antiproliferative activity against human HCT-116 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
ChEMBL ↗
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.
Sun N, Yang K, Yan W, Yao M, Yu C, Duan W, Gu X, Guo D, Jiang H, Xie C, Cheng J.
J Med Chem (2023) 66 : 4802 -4826
PubMed 36934335 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 63 6.19 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5394047 — — 1 7.30
CHEMBL5432435 — — 1 7.22
CHEMBL5414898 — — 1 7.10
CHEMBL5415232 — — 1 7.05
CHEMBL5412296 — — 1 7.00
CHEMBL5409269 — — 1 7.00
CHEMBL5399990 — — 1 6.96
CHEMBL5409329 — — 1 6.96
CHEMBL5418711 — — 1 6.89
CHEMBL5416888 — — 1 6.89
CHEMBL5430562 — — 1 6.89
CHEMBL5430899 — — 1 6.82
CHEMBL5414308 — — 1 6.66
CHEMBL5418707 — — 1 6.64
CHEMBL5428984 — — 1 6.58
CHEMBL5394186 — — 1 6.58
CHEMBL5406785 — — 1 6.55
CHEMBL5407078 — — 1 6.52
CHEMBL98 VORINOSTAT 4.0 1 6.52
CHEMBL5395571 — — 1 6.51
CHEMBL5394727 — — 1 6.44
CHEMBL5423472 — — 1 6.41
CHEMBL5423614 — — 1 6.41
CHEMBL5393893 — — 1 6.39
CHEMBL5408897 — — 1 6.33
CHEMBL5439859 — — 1 6.32
CHEMBL5426015 — — 1 6.28
CHEMBL272980 MOCETINOSTAT 2.0 1 6.28
CHEMBL5396288 — — 1 6.28
CHEMBL5396074 — — 1 6.26

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5394047 — IC50 = 50.0 nM 7.30
CHEMBL5432435 — IC50 = 60.0 nM 7.22
CHEMBL5414898 — IC50 = 80.0 nM 7.10
CHEMBL5415232 — IC50 = 90.0 nM 7.05
CHEMBL5412296 — IC50 = 100.0 nM 7.00
CHEMBL5409269 — IC50 = 100.0 nM 7.00
CHEMBL5399990 — IC50 = 110.0 nM 6.96
CHEMBL5409329 — IC50 = 110.0 nM 6.96
CHEMBL5418711 — IC50 = 130.0 nM 6.89
CHEMBL5416888 — IC50 = 130.0 nM 6.89
CHEMBL5430562 — IC50 = 130.0 nM 6.89
CHEMBL5430899 — IC50 = 150.0 nM 6.82
CHEMBL5414308 — IC50 = 220.0 nM 6.66
CHEMBL5418707 — IC50 = 230.0 nM 6.64
CHEMBL5394186 — IC50 = 260.0 nM 6.58
CHEMBL5428984 — IC50 = 260.0 nM 6.58
CHEMBL5406785 — IC50 = 280.0 nM 6.55
CHEMBL5407078 — IC50 = 300.0 nM 6.52
CHEMBL98 VORINOSTAT IC50 = 300.0 nM 6.52
CHEMBL5395571 — IC50 = 310.0 nM 6.51
CHEMBL5394727 — IC50 = 360.0 nM 6.44
CHEMBL5423472 — IC50 = 390.0 nM 6.41
CHEMBL5423614 — IC50 = 390.0 nM 6.41
CHEMBL5393893 — IC50 = 410.0 nM 6.39
CHEMBL5408897 — IC50 = 470.0 nM 6.33
CHEMBL5439859 — IC50 = 480.0 nM 6.32
CHEMBL272980 MOCETINOSTAT IC50 = 530.0 nM 6.28
CHEMBL5396288 — IC50 = 520.0 nM 6.28
CHEMBL5426015 — IC50 = 530.0 nM 6.28
CHEMBL5396074 — IC50 = 550.0 nM 6.26
CHEMBL5431071 — IC50 = 560.0 nM 6.25
CHEMBL5401053 — IC50 = 630.0 nM 6.20
CHEMBL5398443 — IC50 = 790.0 nM 6.10
CHEMBL5431448 — IC50 = 810.0 nM 6.09
CHEMBL5425472 — IC50 = 870.0 nM 6.06
CHEMBL5404095 — IC50 = 910.0 nM 6.04
CHEMBL5430331 — IC50 = 940.0 nM 6.03
CHEMBL5418509 — IC50 = 1040.0 nM 5.98
CHEMBL5401406 — IC50 = 1060.0 nM 5.97
CHEMBL5400985 — IC50 = 1060.0 nM 5.97
CHEMBL5406417 — IC50 = 1080.0 nM 5.97
CHEMBL5398608 — IC50 = 1090.0 nM 5.96
CHEMBL5415351 — IC50 = 1160.0 nM 5.94
CHEMBL5415734 — IC50 = 1140.0 nM 5.94
CHEMBL3621988 TUCIDINOSTAT IC50 = 1180.0 nM 5.93
CHEMBL5428663 — IC50 = 1450.0 nM 5.84
CHEMBL5435640 — IC50 = 1740.0 nM 5.76
CHEMBL5402175 — IC50 = 1800.0 nM 5.75
CHEMBL5433525 — IC50 = 1770.0 nM 5.75
CHEMBL5440015 — IC50 = 1840.0 nM 5.74