Assay Detail
Functional
CHEMBL5383390
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC-9 cells assessed as reduction of cell viability incubated for 72 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.30 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415232 | — | — | 1 | 6.75 |
| CHEMBL5431071 | — | — | 1 | 6.60 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 6.46 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.93 |
| CHEMBL3621988 | TUCIDINOSTAT | 3.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415232 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL5431071 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1181.0 | nM | 5.93 |
| CHEMBL3621988 | TUCIDINOSTAT | IC50 | = | 1714.0 | nM | 5.77 |