Assay Detail
Binding
CHEMBL5383482
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Inhibition of Agaricus bisporus tyrosinase using L-dopa as substrate preincubated with compound for 20 mins followed by substrate addition measured after 5 mins by absorbance based assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.44 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406189 | — | — | 1 | 7.19 |
| CHEMBL5393798 | — | — | 1 | 6.78 |
| CHEMBL5438907 | — | — | 1 | 6.77 |
| CHEMBL5405962 | — | — | 1 | 6.74 |
| CHEMBL5396344 | — | — | 1 | 6.74 |
| CHEMBL5439545 | — | — | 1 | 6.72 |
| CHEMBL5428226 | — | — | 1 | 6.72 |
| CHEMBL253564 | — | — | 1 | 6.67 |
| CHEMBL5410257 | — | — | 1 | 6.62 |
| CHEMBL5410482 | — | — | 1 | 6.61 |
| CHEMBL5408803 | — | — | 1 | 6.54 |
| CHEMBL5417720 | — | — | 1 | 6.20 |
| CHEMBL5423124 | — | — | 1 | 6.19 |
| CHEMBL5411726 | — | — | 1 | 5.84 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.31 |
| CHEMBL5397629 | — | — | 1 | - |
| CHEMBL360162 | — | — | 1 | - |
| CHEMBL5422567 | — | — | 1 | - |
| CHEMBL5415678 | — | — | 1 | - |
| CHEMBL192877 | DAVIDIGENIN | — | 1 | - |
| CHEMBL5405611 | — | — | 1 | - |
| CHEMBL5405667 | — | — | 1 | - |
| CHEMBL5412375 | — | — | 1 | - |
| CHEMBL5412138 | — | — | 1 | - |
| CHEMBL5426054 | — | — | 1 | - |
| CHEMBL5407617 | — | — | 1 | - |
| CHEMBL490352 | — | — | 1 | - |
| CHEMBL580442 | — | — | 1 | - |
| CHEMBL5414103 | — | — | 1 | - |
| CHEMBL5407705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406189 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5393798 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL5438907 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL5405962 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL5396344 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5439545 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL5428226 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL253564 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL5410257 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL5410482 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL5408803 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL5417720 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL5423124 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL5411726 | — | IC50 | = | 1431.0 | nM | 5.84 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL5410671 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5415070 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5403271 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5418437 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5397629 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5422567 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5415678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL192877 | DAVIDIGENIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL5405611 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5405667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412375 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412138 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5426054 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5407617 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL490352 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL580442 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5414103 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5407705 | — | IC50 | > | 10000.0 | nM | - |