Assay Detail
Binding
CHEMBL5383483
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Inhibition of Agaricus bisporus tyrosinase using L-tyrosine as substrate preincubated with compound for 20 mins followed by substrate addition measured after 10 mins by absorbance based assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.82 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406189 | — | — | 1 | 7.30 |
| CHEMBL5393798 | — | — | 1 | 7.27 |
| CHEMBL5408803 | — | — | 1 | 7.16 |
| CHEMBL5396344 | — | — | 1 | 7.16 |
| CHEMBL5410482 | — | — | 1 | 7.16 |
| CHEMBL253564 | — | — | 1 | 7.14 |
| CHEMBL5438907 | — | — | 1 | 7.05 |
| CHEMBL5405962 | — | — | 1 | 6.96 |
| CHEMBL5428226 | — | — | 1 | 6.92 |
| CHEMBL5410257 | — | — | 1 | 6.91 |
| CHEMBL5439545 | — | — | 1 | 6.88 |
| CHEMBL5417720 | — | — | 1 | 6.74 |
| CHEMBL5423124 | — | — | 1 | 6.63 |
| CHEMBL5411726 | — | — | 1 | 6.48 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.53 |
| CHEMBL5397629 | — | — | 1 | - |
| CHEMBL360162 | — | — | 1 | - |
| CHEMBL5422567 | — | — | 1 | - |
| CHEMBL5415678 | — | — | 1 | - |
| CHEMBL192877 | DAVIDIGENIN | — | 1 | - |
| CHEMBL5405611 | — | — | 1 | - |
| CHEMBL5405667 | — | — | 1 | - |
| CHEMBL5412375 | — | — | 1 | - |
| CHEMBL5412138 | — | — | 1 | - |
| CHEMBL5426054 | — | — | 1 | - |
| CHEMBL5407617 | — | — | 1 | - |
| CHEMBL490352 | — | — | 1 | - |
| CHEMBL580442 | — | — | 1 | - |
| CHEMBL5414103 | — | — | 1 | - |
| CHEMBL5407705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406189 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5393798 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5408803 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5396344 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5410482 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL253564 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5438907 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5405962 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5428226 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL5410257 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL5439545 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5417720 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5423124 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL5411726 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL5410671 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5415070 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5403271 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5418437 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5397629 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5422567 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5415678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL192877 | DAVIDIGENIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL5405611 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5405667 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412375 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412138 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5426054 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5407617 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL490352 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL580442 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5414103 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5407705 | — | IC50 | > | 10000.0 | nM | - |