Assay Detail
Binding
CHEMBL5383554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from GluN2B in mouse LTK cells assessed as inhibition constant measured after 120 mins by scintillation counting method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | LTK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL3442) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Conformationally Restricted σ<sub>1</sub> Receptor Antagonists from (-)-Isopulegol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.88 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 9.22 |
| CHEMBL493054 | — | — | 1 | 9.10 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.89 |
| CHEMBL5415339 | — | — | 1 | 7.44 |
| CHEMBL5435693 | — | — | 1 | 7.35 |
| CHEMBL73824 | — | — | 1 | 7.31 |
| CHEMBL5413704 | — | — | 1 | 7.28 |
| CHEMBL5418583 | — | — | 1 | 7.21 |
| CHEMBL5430693 | — | — | 1 | 7.04 |
| CHEMBL5408176 | — | — | 1 | 6.90 |
| CHEMBL5421431 | — | — | 1 | 6.69 |
| CHEMBL5419171 | — | — | 1 | 6.58 |
| CHEMBL5419345 | — | — | 1 | 6.57 |
| CHEMBL5427418 | — | — | 1 | 6.50 |
| CHEMBL5440135 | — | — | 1 | 6.44 |
| CHEMBL5394456 | — | — | 1 | 6.43 |
| CHEMBL5439989 | — | — | 1 | 6.39 |
| CHEMBL5409031 | — | — | 1 | 6.37 |
| CHEMBL5395928 | — | — | 1 | 6.29 |
| CHEMBL5438476 | — | — | 1 | 6.29 |
| CHEMBL5420805 | — | — | 1 | 6.05 |
| CHEMBL5419756 | — | — | 1 | 5.97 |
| CHEMBL5436332 | — | — | 1 | 5.89 |
| CHEMBL5402137 | — | — | 1 | 5.89 |
| CHEMBL2170062 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL493054 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5415339 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL5435693 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL73824 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL5413704 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL5418583 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL5430693 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL5408176 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL5421431 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL5419171 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL5419345 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL5427418 | — | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL5440135 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL5394456 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL5439989 | — | Ki | = | 408.0 | nM | 6.39 |
| CHEMBL5409031 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL5395928 | — | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL5438476 | — | Ki | = | 508.0 | nM | 6.29 |
| CHEMBL5420805 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL5419756 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL5436332 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL5402137 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2170062 | — | Ki | > | 58.0 | nM | - |