Assay Detail
Binding
CHEMBL5383650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 JH2 in human TF-1 cells assessed as reduction of IFNalpha induced STAT1 phosphorylation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | TF-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.66 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405538 | — | — | 1 | 8.15 |
| CHEMBL5433451 | — | — | 1 | 8.10 |
| CHEMBL5428659 | — | — | 1 | 7.42 |
| CHEMBL5424441 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405538 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5433451 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5428659 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5424441 | — | IC50 | = | 112.0 | nM | 6.95 |