Assay Detail
Binding
CHEMBL5383674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 JH2 (561 to 860 residues) (unknown origin) by HTRF assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.72 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5427277 | — | — | 1 | 10.80 |
| CHEMBL5422022 | — | — | 1 | 10.74 |
| CHEMBL5416227 | — | — | 1 | 10.59 |
| CHEMBL5418288 | — | — | 1 | 10.59 |
| CHEMBL5420349 | — | — | 1 | 10.57 |
| CHEMBL5417355 | — | — | 1 | 10.42 |
| CHEMBL5433889 | — | — | 1 | 7.10 |
| CHEMBL5398472 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5427277 | — | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL5422022 | — | IC50 | = | 0.018 | nM | 10.74 |
| CHEMBL5416227 | — | IC50 | = | 0.026 | nM | 10.59 |
| CHEMBL5418288 | — | IC50 | = | 0.026 | nM | 10.59 |
| CHEMBL5420349 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL5417355 | — | IC50 | = | 0.038 | nM | 10.42 |
| CHEMBL5433889 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5398472 | — | IC50 | = | 117.0 | nM | 6.93 |