Assay Detail
Binding
CHEMBL5383676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-12 induced STAT4 phosphorylation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NK92 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.24 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5418288 | — | — | 1 | 10.28 |
| CHEMBL5420349 | — | — | 1 | 9.00 |
| CHEMBL5422022 | — | — | 1 | 8.92 |
| CHEMBL5416227 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5418288 | — | IC50 | = | 0.053 | nM | 10.28 |
| CHEMBL5420349 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5422022 | — | IC50 | = | 1.21 | nM | 8.92 |
| CHEMBL5416227 | — | IC50 | = | 1.82 | nM | 8.74 |