JAK2/TYK2 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt O60674. Use UniProt O60674 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O60674 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase JAK2
Review this target as JAK2/TYK2, mapped to UniProt O60674. ChEMBL maps the protein component as Tyrosine-protein kinase JAK2. Sequence length is 1132 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats JAK2/TYK2 as ChEMBL target CHEMBL3301392, mapped to UniProt O60674. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | JAK2/TYK2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | O60674 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase JAK2 |
| UniProt Accession | O60674 |
| Component Type | Protein |
| Sequence Length | 1132 aa |
Tyrosine-protein kinase JAK2
Review this target as JAK2/TYK2, mapped to UniProt O60674. ChEMBL maps the protein component as Tyrosine-protein kinase JAK2. Sequence length is 1132 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5418288 | 10.28 | IC50 | 0.053 | Preclinical |
| CHEMBL5420928 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL5413489 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL5440264 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5420349 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5422022 | 8.92 | IC50 | 1.21 | Preclinical |
| CHEMBL5416227 | 8.74 | IC50 | 1.82 | Preclinical |
| CHEMBL5397906 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5441067 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4548200 | 7.57 | IC50 | 27.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 14 | 16 | 8.1 |
| tissue-based format | 7 | 2 | 6.5 |
| protein complex format | 5 | 7 | 5.9 |
| assay format | 1 | 24 | 6.3 |