Compound Detail
CHEMBL5420928
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Basic Information
| ChEMBL ID | CHEMBL5420928 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SKSCGXZQWKQMTE-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
412.4
MW (Da)
2.50
ALogP
7
HBA
2
HBD
106.3
PSA (Ų)
0.66
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 10.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| JAK2/TYK2 CHEMBL3301392 | IC50 | 10.1 | 10.1 | 0.1 | 1 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Tyrosine-protein kinase JAK1 CHEMBL2835 | IC50 | 7.42 | 7.42 | 38.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| JAK2/TYK2 | IC50 | = | 0.08 | nM | 10.1 | Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed... | 36951608 |
| Tyrosine-protein kinase JAK3 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of human recombinant JAK3 preincubated for 15 mins followed by substr... | 36951608 |
| Tyrosine-protein kinase JAK2 | IC50 | = | 4.0 | nM | 8.4 | Inhibition of human recombinant JAK2 preincubated for 15 mins followed by substr... | 36951608 |
| Tyrosine-protein kinase JAK1 | IC50 | = | 38.0 | nM | 7.42 | Inhibition of human recombinant JAK1 preincubated for 15 mins followed by substr... | 36951608 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36951608 | 10.1021/acs.jmedchem.2c01800 | Tyrosine-protein kinase JAK1 | 1 |
| 36951608 | 10.1021/acs.jmedchem.2c01800 | Tyrosine-protein kinase JAK2 | 1 |
| 36951608 | 10.1021/acs.jmedchem.2c01800 | Tyrosine-protein kinase JAK3 | 1 |
| 36951608 | 10.1021/acs.jmedchem.2c01800 | Non-receptor tyrosine-protein kinase TYK2 | 1 |
| 36951608 | 10.1021/acs.jmedchem.2c01800 | JAK2/TYK2 | 1 |
Data from ChEMBL 36 via Core Engine