Assay Detail
Binding
CHEMBL5383632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK2/TYK2 signal transduction pathway in human NK92 cells assessed as IL-2 induced IFNgamma expression incubated for 24 hrs by ELISA assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NK92 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.67 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5420928 | — | — | 1 | 10.10 |
| CHEMBL5413489 | — | — | 1 | 9.52 |
| CHEMBL5440264 | — | — | 1 | 9.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5420928 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL5413489 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5440264 | — | IC50 | = | 0.4 | nM | 9.40 |