Assay Detail
Binding
CHEMBL5384094
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Inhibition of SOS1/KRAS (unknown origin) protein-protein interaction
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.66 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4535474 | BAY-293 | — | 1 | 7.68 |
| CHEMBL4520788 | BAY-294 | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4535474 | BAY-293 | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4520788 | BAY-294 | IC50 | = | 2340.0 | nM | 5.63 |