Assay Detail
Functional
CHEMBL5384424
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Antagonist activity at human H3 receptor
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Advances in Epilepsy: Mechanisms, Clinical Trials, and Drug Therapies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.58 | 8.08 |
| IC50 | 1 | 8.23 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434282 | — | — | 1 | 8.23 |
| CHEMBL4173079 | — | — | 1 | 8.08 |
| CHEMBL4162433 | — | — | 1 | 7.80 |
| CHEMBL1789558 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434282 | — | IC50 | = | 5.92 | nM | 8.23 |
| CHEMBL4173079 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL4162433 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL1789558 | — | Ki | = | 141.25 | nM | 6.85 |