Assay Detail
Functional
CHEMBL5384523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against pseudotyped Ebola virus infected in HeLa cells preincubated for 1 hr followed by viral infection and measured after 48 hrs by steady-glo luciferase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
<i>N</i>'-Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic Profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.14 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414982 | — | — | 1 | 7.30 |
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 7.16 |
| CHEMBL5398314 | — | — | 1 | 6.80 |
| CHEMBL5395997 | — | — | 1 | 6.57 |
| CHEMBL5172194 | — | — | 1 | 6.43 |
| CHEMBL5433897 | — | — | 1 | 6.24 |
| CHEMBL5402943 | — | — | 1 | 5.98 |
| CHEMBL5416183 | — | — | 1 | 5.89 |
| CHEMBL5426718 | — | — | 1 | 5.77 |
| CHEMBL5428579 | — | — | 1 | 5.66 |
| CHEMBL5424648 | — | — | 1 | 5.62 |
| CHEMBL5396731 | — | — | 1 | 5.55 |
| CHEMBL5424177 | — | — | 1 | 5.50 |
| CHEMBL5395403 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414982 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1655 | TOREMIFENE | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5398314 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5395997 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5172194 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5433897 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5402943 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5416183 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5426718 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5428579 | — | EC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL5424648 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5396731 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5424177 | — | EC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL5395403 | — | EC50 | = | 3630.0 | nM | 5.44 |