Assay Detail
Binding
CHEMBL5384769
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Binding affinity to DYRK1B (unknown origin) assessed as dissociation constant by competitive binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (CHEMBL5543) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Inhibitors of CDK8 for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 5.89 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5434183 | — | — | 1 | 6.48 |
| CHEMBL5416758 | — | — | 1 | 5.89 |
| CHEMBL5414359 | — | — | 1 | 5.85 |
| CHEMBL5425043 | — | — | 1 | 5.68 |
| CHEMBL5396725 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5434183 | — | Kd | = | 330.0 | nM | 6.48 |
| CHEMBL5416758 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL5414359 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL5425043 | — | Kd | = | 2100.0 | nM | 5.68 |
| CHEMBL5396725 | — | Kd | = | 2700.0 | nM | 5.57 |