Assay Detail
Binding
CHEMBL5384773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to VPS34 (unknown origin) assessed as dissociation constant by competitive binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase catalytic subunit type 3 (CHEMBL1075165) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Inhibitors of CDK8 for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 6.31 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416758 | — | — | 1 | 7.70 |
| CHEMBL5434183 | — | — | 1 | 7.17 |
| CHEMBL5414359 | — | — | 1 | 5.75 |
| CHEMBL5425043 | — | — | 1 | 5.54 |
| CHEMBL5396725 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416758 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL5434183 | — | Kd | = | 68.0 | nM | 7.17 |
| CHEMBL5414359 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL5425043 | — | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL5396725 | — | Kd | = | 4200.0 | nM | 5.38 |